Constructed growth charts and nutrition for pontocerebellar hypoplasia type 2A.

The cohort was small, with 65 participants and seven missing follow-up data, so comparisons, especially between PEG-fed and non-PEG-fed children, were limited. Measurements came from different health professionals and parents, and the instruments used were not recorded, so standardization was limited. Caloric intake was calculated or estimated by parents without standard software, so diet details are not fully comparable. Most data were collected in the first 2 years of life, and only few measurements were available after 15 years, so centiles in older children are less secure. The cohort was mostly German and included nine sibling pairs, and it was compared with a German reference group, so results may not apply to other populations. The researchers did not correct for multiple comparisons, so some significant differences may be chance. The charts describe care reality in one cohort, not an ideal growth target.

The Chan Zuckerberg Initiative funded the study. No additional conflict-of-interest declaration was included in the supplied text.

Do not treat these centiles as ideal growth or conclude that PEG feeding fixes weight gain. They describe what happened in a small PCH2A cohort, and weight gain did not follow one pattern in participants with PEG feeding.