Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil.
Juliana Barros Becker, Valdir Ambrósio Moisés, Dulce Aparecida Barbosa
PMID 40743530WHAT IT FOUND
In 204 patients with infective endocarditis, 45% died during hospital stay and short-term mortality reached 51%.
Healthcare-associated infection drove most cases. Diabetes and acute kidney injury predicted readmission, but no single factor independently predicted short-term death.
Key findings
01In-hospital mortality was 44.6% (91 of 204 patients), and total deaths including six-month follow-up reached 104 patients.
02Healthcare-associated infective endocarditis accounted for 62.3% of cases, with non-nosocomial acquisition being more common than nosocomial.
03Diabetes and acute kidney injury were independent risk factors for hospital readmission, but no independent risk factor was identified for short-term mortality.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Single-centre study limits generalisability to other regions or hospital types. Retrospective design relies on medical records, which may have missing or incomplete data. Follow-up was limited to six months, so long-term outcomes beyond this period are unknown. The study population may not reflect the diversity of infective endocarditis cases in other parts of Brazil or other countries.
The easy way to misread this
Do not assume that specific clinical features like age or comorbidities can independently predict short-term mortality in this cohort, as the multivariate analysis found no such independent risk factors. The high mortality is multifactorial and driven by complications like septic shock and healthcare-associated infections rather than a single identifiable predictor.