Characteristics of Autism Spectrum Disorder in Sotos Syndrome.
Chloe Lane, Elizabeth Milne, Megan Freeth
PMID 27771801WHAT IT FOUND
In 78 people with Sotos syndrome, 65 had parent-reported autism symptom scores in a clinical range.
Restricted interests and repetitive behaviour scores were higher than social communication scores. Gender did not affect severity.
Key findings
01Of 78 people with Sotos syndrome, 65 had parent-reported autism symptom scores in a clinical range.
02Restricted interests and repetitive behaviours scores were higher than social communication impairment scores in the same group.
03Autism symptom severity did not differ by gender, but was lower in early childhood and adulthood than in childhood.
STILL TO COME
How it was doneWhat they foundWhat it means for SLPs
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What it does not show
The study used a family-report questionnaire and did not use clinical evaluation to confirm autism. Developmental level, cognitive ability, and verbal ability were not collected, although the paper says these factors may affect ASD symptomatology. The age comparison was cross-sectional, not longitudinal. Comparison data came from a published paper, not from controls recruited in this study. Families were recruited through a charity and social media advertisements, and eligibility was based on reported diagnosis.
Declared interests
The Child Growth Foundation funded the study. The paper does not report other conflict-of-interest statements.
The easy way to misread this
Do not treat the high questionnaire scores as proof that most people with Sotos syndrome have autism. The study measured autistic symptomatology with a family-report questionnaire, not clinical diagnosis, and only some participants had a reported autism diagnosis.