Bio-collections in autism research.
Jamie Reilly, Louise Gallagher, June L Chen and 2 others
PMID 28702161WHAT IT FOUND
Large autism research collections have supported genetic studies of autism, including studies of language and communication differences.
They are research resources, not clinical tests or treatments.
Key findings
01Large public autism bio-collections have supported genetic studies of autism, including AGRE and SSC.
02AGRE contains over 2500 families and has contributed to high-profile genetic discoveries in autism.
03SSC contains 2600 families and has contributed to whole exome sequencing studies in autism.
STILL TO COME
How it was doneWhat they foundWhat it means for SLPs
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What it does not show
This is a review of research resources, not a clinical trial or diagnostic study, so it does not show that any therapy or test works. The collections differ in samples, diagnoses and clinical data, so results may not apply to all autistic patients. Many studies rely heavily on people of European descent, which can limit generalisability. Some genetic findings did not replicate when tested in other collections. The inpatient collection has not yet been used in genetics studies, and stem-cell models are still early-stage.
Declared interests
The supplied text does not include an author conflict-of-interest declaration. It says AGRE is managed by Autism Speaks, TASC was funded by Autism Speaks, and MSSNG is an initiative of Autism Speaks with Google and Genome Canada.
The easy way to misread this
Do not read this review as evidence that genetic findings from autism research collections can guide assessment or therapy for an individual patient. It describes research resources and genetic studies, not clinical outcomes.