Association between height-corrected appendicular and regional skeletal muscle mass and insulin resistance in patients with type 2 diabetes.
Yoshikazu Hirasawa, Yoshiyuki Hamamoto
PMID 35527846WHAT IT FOUND
Greater height-corrected leg muscle mass was linked to lower insulin resistance in men and non-obese women with type 2 diabetes.
In obese women, height-corrected limb muscle mass was linked to higher insulin resistance. This is an association, not proof.
Key findings
01Height-corrected total limb muscle mass and height-corrected lower-limb muscle mass were linked to lower insulin resistance in men with type 2 diabetes, in both non-obese and obese groups.
02The same inverse associations were seen in non-obese women with type 2 diabetes.
03In obese women with type 2 diabetes, height-corrected total limb muscle mass was linked to higher insulin resistance, and height-corrected upper-limb, lower-limb, and trunk muscle mass were not selected.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
The study looked at one time point, so it cannot show whether low muscle mass caused insulin resistance or insulin resistance contributed to low muscle mass. It was done at one hospital in Japan, so it may not apply to other countries or ethnic groups. Muscle mass was estimated with bioelectrical impedance, which may not match actual muscle mass. The sample was split into sex and obesity subgroups, and the authors said the sample size was small. Patients were not using insulin or oral glucose-lowering drugs, so results may not apply to people with more advanced or treated type 2 diabetes.
Declared interests
The authors reported no funding or conflicts of interest.
The easy way to misread this
Do not read this as proof that building muscle improves insulin resistance. The study was cross-sectional and did not test an exercise intervention, and in obese women higher appendicular muscle-mass index was associated with higher insulin resistance.