Androgen Deprivation and Sleep Disturbance: A Mixed Methods Pilot Study of Remote Assessment and Intervention.
Jamie S Myers, Catherine Siengsukon, Joseph Sherman and 7 others
PMID 35439217WHAT IT FOUND
Men with prostate cancer on androgen deprivation therapy reported better sleep after a 4-week remote cognitive behavioral therapy program.
Device-measured sleep did not change, and the study had no control group.
Key findings
01Self-reported sleep quality improved by 3.8 points and insomnia severity improved by 8.5 points after teleCBT-I.
02Device-measured sleep metrics did not change significantly after the intervention.
03All 15 recruited men were retained and attended 100% of weekly teleCBT-I sessions.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study was a single-arm pilot with 15 men, so there was no control group and the results cannot show that teleCBT-I caused the changes. Follow-up was short, and cognitive function was not reassessed after the intervention because of the risk of practice effects. Two participants were receiving venlafaxine or gabapentin for hot flashes, and one increased the dose during the first study week, so hot flash changes cannot be separated from medication. Accelerometer analyses included 13 participants, and post-intervention wear time decreased by about 120 minutes per day, which may affect activity and sleep comparisons. Qualitative interviews included 14 of 15 participants, and some participants found hearing the study team challenging because of hearing loss. Remote fitness testing was not possible for two participants because of injury or balance problems, so feasibility may differ for patients with more disability.
Declared interests
This pilot was supported by a University of Kansas Cancer Center 2020 Spring Pilot Project Grant and Cancer Center Support Grant P30CA168524. The authors declared no conflicts of interest.
The easy way to misread this
Do not read the improved questionnaire scores as proof that teleCBT-I works for ADT-related sleep disturbance. This was a single-arm pilot of 15 men with no control group, and device-measured sleep metrics did not change significantly.