A systematic variant annotation approach for ranking genes associated with autism spectrum disorders.

This is a database and scoring analysis, not a study of patients, therapy outcomes or diagnosis. The text reports 771 common variants after filtration but later states 711 common variants in the dataset. Scores depend on published variant counts and publications, so genes studied more often can score higher; the authors describe this as a winner's curse. Scoring weights were partly based on published evidence and expert opinion, so the ranking is not a purely statistical result. The analysis excluded variants linked to intellectual disability, epilepsy, schizophrenia or bipolar disorder unless ASD was also diagnosed, so it does not address those conditions. Common variants with small effect sizes remain poorly understood and often lack replication in ASD. The paper does not report individual patients, clinical severity, prognosis or treatment response.

The supplied text does not include a funding or conflict-of-interest statement.

Do not read this as a clinical test or treatment guide. It ranks genes from published genetic studies, not patients, and it reports no therapy outcomes.