A randomized controlled trial on the effects of traditional Thai mind-body exercise (Ruesi Dadton) on biomarkers in mild cognitive impairment.
Phaksachiphon Khanthong, Kusuma Sriyakul, Ananya Dechakhamphu and 4 others
PMID 38814196WHAT IT FOUND
In older adults with mild cognitive impairment, 12 weeks of Thai mind-body exercise plus education increased blood BDNF and SIRT1 levels in the exercise group.
BDNF was higher than in the education-only group. Cognitive outcomes were not reported.
Key findings
01BDNF levels differed significantly between the exercise and control groups, while SIRT1 levels did not.
02Within the exercise group, BDNF and SIRT1 changed significantly from pre to post, while the control group did not show significant change.
03The combined blood biomarker analysis was significant for group, time, and group-by-time interaction.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
The outcomes were blood biomarkers, not cognitive, functional, or patient-centred results. No post-intervention MMSE or MoCA results were reported in the supplied text. Twenty-nine participants per group were analysed after excluding outlier laboratory data. The exercise group also received education and group social contact, so the contribution of these components cannot be separated. One-third of the exercise group did not reach WHO-recommended exercise intensity. Risk factors such as apolipoprotein E allele, mental conditions, and other diseases were not known.
Declared interests
The authors declared no conflicts of interest. The study was funded by the Thai Traditional Medical Knowledge Fund, Department of Thai Traditional and Alternative Medicine, Ministry of Public Health. The authors said the sponsor did not influence the outcome.
The easy way to misread this
Do not conclude that this exercise prevents or treats cognitive decline. The study measured blood biomarkers after 12 weeks and did not report cognitive outcomes, and the exercise group also received education and group social contact.