PTOtherJournal of neuroengineering and rehabilitation2024

A comprehensive multivariate analysis of the center of pressure during quiet standing in patients with Parkinson's disease.

Shintaro Fujii, Yusaku Takamura, Koki Ikuno and 2 others

PMID 38654376

WHAT IT FOUND

Quiet standing sway in Parkinson's disease split into five components and six subtypes.

Sway area and speed alone did not separate mild from severe PD, so PTs may need to look beyond one sway number.

Key findings

01Quiet standing sway in PD patients compressed into five components of postural control.

02A cluster analysis classified 174 older adults and PD patients into six sway subtypes.

03Sway area and mean speed were higher in older adults, mild PD, and severe PD than in young adults, but did not differ between mild and severe PD.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

The study did not test any rehabilitation intervention, so it cannot show that any treatment improves balance. It measured quiet standing only and did not directly assess falls, so the subtypes are not fall-risk categories. All participants had to stand quietly for 30 seconds without assistance, so people with more severe balance problems were excluded. Before the main results, 11 PD patients, four older adults, and two young adults were removed as outliers. The balance recording was a single 30 second sample, not repeated trials. PD patients were measured in their usual medication state, not a controlled on/off comparison. The six subtypes were created by the analysis and were not checked against follow-up, treatment response, or a separate group. The clustering method was chosen to separate groups, so the clear cluster separation may partly come from the analysis method.

Declared interests

The supplied article metadata lists non-U.S. government research support. The article text does not include an author conflict-of-interest declaration.

The easy way to misread this

Do not treat the six sway subtypes as clinical diagnoses or fall-risk groups. The study measured quiet standing patterns and did not test rehabilitation or assess falls.

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The study

Participants
127 PD patients, 47 older healthy adults, and 71 young healthy adults analysed; originally 138 PD patients, 51 older healthy adults, and 73 young healthy adults were enrolled.
Certainty of evidence
Low

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Shintaro Fujii, Yusaku Takamura, Koki Ikuno, et al. A comprehensive multivariate analysis of the center of pressure during quiet standing in patients with Parkinson's disease. Journal of neuroengineering and rehabilitation. 2024.

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