Willingness to Participate in Clinical Research Among Individuals With Cognitive Impairment.
Mengchi Li, Hyejin Kim, Susan M Sereika and 2 others
PMID 35148207WHAT IT FOUND
Among patients with cognitive impairment, higher trust in researchers was linked to willingness to join a hypothetical drug trial, while lower cognitive test scores were linked to willingness to join a hypothetical surgical trial.
Patient and caregiver ratings often disagreed.
Key findings
01Higher trust in medical researchers was independently associated with being likely or extremely likely to participate in the drug trial.
02For the surgical trial, only MMSE remained a significant predictor, with higher MMSE scores associated with greater odds of being not or somewhat likely to participate.
03Agreement between patient and care partner willingness ratings was very poor for both drug and surgical trial vignettes.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The sample was small and self-selected, with 92% Caucasian and high education, so it may not represent people with cognitive impairment in the community. The study used hypothetical trial scenarios, not real enrollment offers, so actual decisions may differ. Participants had already agreed to take part in the parent study, which may make them more willing to agree to research. The analysis excluded people with inadequate comprehension of the study, so it says little about those who cannot understand a research offer. Data from care partners were insufficient to analyze what influences their willingness to enroll a loved one. Missing questionnaire responses reduced the final predictive models to 47 patients for the drug vignette and 46 patients for the surgical vignette. The study did not directly measure whether patients mistook research for treatment.
Declared interests
The supplied text lists NIH extramural and non-U.S. government research support. It does not include an author conflict-of-interest declaration.
The easy way to misread this
Do not read higher trust as a reason to use trust to recruit patients into research. The study found only associations with hypothetical trial willingness in a small selected sample, and it did not directly measure whether patients mistook research for treatment.