What influences interruption of continuous renal replacement therapy in intensive care unit patients: A review with meta-analysis on outcome variables.

The number of included studies was small (15 articles), limiting the robustness of the findings. There was substantial heterogeneity in the results for key factors like filter life and APTT, suggesting differences in how these were measured or managed across studies. The review did not perform meta-regression, so it could not adjust for potential confounders between studies. Findings may not generalize to all ICU populations or CRRT protocols due to regional and procedural variations in the included studies.

The work was supported by a Horizontal Project for Shandong University. No specific conflicts of interest regarding commercial sponsors were declared in the provided text.

Do not interpret the significant correlations as proof that changing these factors will definitely prevent interruptions. The high heterogeneity across studies and the observational nature of the data mean these are associations, not established causal mechanisms. Furthermore, the lack of correlation with patient demographics like age does not mean patient condition is irrelevant, but rather that circuit-specific and coagulation parameters were stronger predictors in this dataset.