OtherMolecular autism2022

WDFY3 mutation alters laminar position and morphology of cortical neurons.

Zachary A Schaaf, Lyvin Tat, Noemi Cannizzaro, Alexios A Panoutsopoulos, Ralph Green, Thomas Rülicke, Simon Hippenmeyer, Konstantinos S Zarbalis

PMID 35733184

WHAT IT FOUND

This study examines brain cell migration in mice with an autism-related gene mutation.

It provides no clinical data on human patients or therapeutic interventions, so there are no findings applicable to physical, occupational, or speech therapy practice.

What this paper is

This is a basic science study using mouse models to investigate how a specific genetic mutation affects brain development at the cellular level. It reports no human patients, no clinical outcomes, and no interventions relevant to physical, occupational, or speech therapy practice. There is nothing here to change your clinical practice on.

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The study

Certainty of evidence
Low

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    Cite

    Zachary A Schaaf, Lyvin Tat, Noemi Cannizzaro, et al. WDFY3 mutation alters laminar position and morphology of cortical neurons. Molecular autism. 2022.

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