Treatment topical with silver nanoparticles and Stryphnodendron Adstringens (Mart.) Coville in cervical lesions: randomized clinical trial.
Cristiane Araújo Nascimento, Ana Caroline Melo Dos Santos, Denise Macedo da Silva and 7 others
PMID 37522745WHAT IT FOUND
Adding silver nanoparticles to a barbatimão gynecological ointment did not show a difference from the ointment without them in 43 women without cervical lesions.
No adverse effects were reported over 7 weeks. This was a safety pilot, not evidence that it treats cervical lesions.
Key findings
01No adverse health-damaging effects were reported after 7 weeks of ointment use.
02Pathogenic microorganisms were identified in 16.3% of samples before use and 34.9% after use.
03Inflammation with atrophy was identified in 9.3% of samples before use and 74.4% after use.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
This was a pilot phase 1 safety study in 43 women, so it cannot show whether the ointment treats cervical lesions. Participants were women without cervical lesions, not the population named in the title, so the results do not apply to women with diagnosed cervical lesions. There was no difference between the ointment with silver nanoparticles and the ointment without silver nanoparticles before or after use. The authors said the main limitation was performing the safety test directly in people. Some findings increased after use, including inflammation with atrophy in 9.3% before use and 74.4% after use, and pathogenic microorganisms in 16.3% before use and 34.9% after use. No funding or conflict of interest declaration is present in the supplied text.
The easy way to misread this
Do not read this as evidence that silver nanoparticles or barbatimão ointment treats cervical lesions. The trial enrolled women without cervical lesions, was a pilot safety study, and did not show a difference between ointment with and without silver nanoparticles.