Transition From Acute to Chronic Pain in Lower Extremity Fracture Patients: A Pain Phenotyping Protocol.
Mari A Griffioen, Joseph Glutting, Robert V O'Toole and 4 others
PMID 31977841WHAT IT FOUND
No results are reported yet.
This protocol plans to follow 240 fracture patients and 40 controls to see which early pain patterns point to chronic pain at 52 weeks.
Key findings
01The protocol plans to follow 240 patients with fibula and/or tibia fracture and 40 controls to identify predictors of chronic pain at 52 weeks.
02Chronic pain at 52 weeks will be defined as a Chronic Pain Grading Scale characteristic pain intensity score of 1 to 30 in the last three months at the fracture site.
03So far, the study has received IRB approval, is screening and enrolling participants, and reports 10% lost to attrition.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
This is a protocol, so it reports no analysed chronic pain outcomes yet. The planned primary outcome is chronic pain yes or no at 52 weeks. Recruitment is a challenge, and 10% of participants have been lost to attrition so far. The gene expression plan uses extreme pain phenotypes, which may miss effects for low, medium, and high pain groups. RNA sequencing can be affected by batch effects or technology changes during the study.
Declared interests
The authors report no conflicts of interest. The publication types list NIH extramural research support.
The easy way to misread this
Do not treat the planned pain phenotyping as tested evidence for which fracture patients will develop chronic pain. No outcomes have been analysed, and the paper reports only protocol details and early recruitment progress.