PTOTCase-ControlArchives of rehabilitation research and clinical translation2026

Thumb Positioning Modulates Median Nerve Mobility and Morphology During Postural Changes in Carpal Tunnel Syndrome: Implications for Nerve Gliding Exercises.

Yi-Wei Chang, Chii-Jen Chen, You-Wei Wang and 2 others

PMID 42769373

WHAT IT FOUND

Thumb abduction reduced median nerve excursion in patients with carpal tunnel syndrome, suggesting nerve gliding exercises should avoid overstretching the thumb during the final step to prevent neural strain.

Key findings

01Median nerve excursion decreased significantly when the thumb was moved to abduction from rest in patients with CTS, but not in healthy controls.

02Median nerve cross-sectional area was significantly smaller in the thumb-abducted position compared to the resting position in both wrist-neutral and wrist-extended postures for patients with CTS.

03Flexor digitorum superficialis tendon excursion increased with thumb abduction in both groups, indicating preserved tendon mechanics despite reduced nerve mobility.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTs

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What it does not show

The study is cross-sectional, so it cannot prove that reduced nerve gliding causes CTS or that specific exercises will improve symptoms. Doppler imaging only captured longitudinal motion and could not detect side-to-side movements of the nerve. Participants with diabetes, thyroid issues, or prior wrist surgery were excluded, limiting generalizability to complex cases.

Declared interests

The investigators have no financial or nonfinancial disclosures to make in relation to this project.

The easy way to misread this

Do not assume that increasing thumb abduction improves nerve gliding. In patients with CTS, thumb abduction actually reduced median nerve excursion, suggesting this position may be counterproductive or excessive for nerve mobilization.

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