The Protective Influence of Chondroitin Sulfate, a Component of Human Milk, on Intestinal Bacterial Invasion and Translocation.
Kathryn Y Burge, Lindsey Hannah, Jeffrey V Eckert and 2 others
PMID 31051086WHAT IT FOUND
Chondroitin sulfate, a human milk component, reduced bacterial invasion and translocation in human intestinal cells in a dish, but did not reduce inflammation or protect barrier function.
Key findings
01Chondroitin sulfate at 750 µg/ml significantly reduced bacterial invasion compared with control.
02Chondroitin sulfate at 750 µg/ml significantly protected against bacterial translocation compared with control.
03Chondroitin sulfate did not significantly reduce IL-8 production during bacterial invasion.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study used only one human intestinal cell line in a dish, not infants or adults. It did not test whether chondroitin sulfate changes NEC risk, feeding outcomes, or safety in infants. The authors state that in vitro results cannot necessarily be extrapolated to an in vivo system. The chondroitin sulfate used was commercially available and derived from shark fin cartilage, not human milk. The IL-8 result followed a brief bacterial exposure, which the authors suggest may explain why inflammation was not reduced.
Declared interests
The authors declared no potential conflicts of interest.
The easy way to misread this
Do not treat this as evidence that chondroitin sulfate supplementation helps infants. The study used human intestinal cells in a dish, not patients, and it did not test infant outcomes.