PTSystematic ReviewBrazilian journal of physical therapy2024

The methodological quality of clinical trials of physical therapy for low back pain varies between countries with different income levels. A meta-epidemiological study.

Carlos Maximiliano Sánchez Medina, Claudia Gutiérrez Camacho, Anne M Moseley and 8 others

PMID 39566201

WHAT IT FOUND

Trials of physical therapy for low back pain run in low- and lower-middle-income countries scored lower on methodological quality than trials from richer countries, 4.8 versus 5.5 points out of 10.

Seven in ten trials came from high-income countries.

Key findings

01Of 2552 trials of physical therapy for low back pain, 1798 (70.4%) were conducted in high-income countries, 604 (23.7%) in upper-middle-income countries and 150 (5.9%) in low- or lower-middle-income countries.

02Mean PEDro score was 4.8 for trials from low- or lower-middle-income countries, 5.4 for upper-middle-income countries and 5.5 for high-income countries; low- or lower-middle-income trials scored 0.7 points lower than high-income trials (95% CI -1.1 to -0.5).

03Intention-to-treat analysis was met by 16.0% of trials from low- or lower-middle-income countries, 25.1% of upper-middle-income trials and 41.2% of high-income trials; concealed allocation was met by 28.7%, 31.0% and 40.4% respectively.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

Income level was judged only from the country of the corresponding author's institution and only from gross national income per capita. The study did not look at other things that affect trial quality, such as who funded a trial or industry sponsorship, or the research expertise, technology and institutional support available to the team. Countries were classified using the World Bank's 2020 income list regardless of when each trial was published, so a country's category may not match its category at the time the trial was done. The PEDro scale was designed for randomised trials and may score trials containing an economic evaluation poorly, although fewer than 2% of the included trials were economic evaluations. Only three databases were searched, and the authors acknowledge they may have missed trials from low- and lower-middle-income countries published in languages other than English, in local journals or as grey literature. Most included trials came from a small number of countries.

Declared interests

The authors declare no competing interests. The supplied text contains no funding statement, so who paid for the work is not reported here.

The easy way to misread this

Do not read this as evidence that physical therapy for low back pain is worse, or better, in poorer countries. The study only scored how trials were conducted, not how patients responded, and the gap it found was 0.7 points on a 10-point scale. It also cannot tell you whether an individual trial from a low- or lower-middle-income country is trustworthy, only what the average looks like across 2552 trials.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →