The Influence of Sedentary Behavior on the Relationship Between Cognitive Function and Vascular Function in Older Adults with and without Chronic Kidney Disease.
Mary Hannan, Eileen G Collins, Shane A Phillips and 3 others
PMID 34935333WHAT IT FOUND
Sedentary time and breaks did not show a clear link to how blood vessel stiffness or dilation related to cognitive test scores in older adults with and without chronic kidney disease.
In those without kidney disease, one exploratory subgroup suggested a link.
Key findings
01No interaction term for sedentary time or sedentary breaks reached p < 0.05 in the moderation analyses of the whole sample.
02Participants with chronic kidney disease had a lower mean MoCA score than participants without chronic kidney disease, 23.04 versus 26.79.
03In participants without chronic kidney disease, sedentary time moderated the relationship between cfPWV and MoCA score, with an R² increase of 0.15 and interaction p = 0.04.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study was exploratory and was not powered to support significant associations. The paper does not state the total number of participants analysed. The sample was a convenience sample. The design was cross-sectional, so it cannot show that sedentary behavior causes or prevents cognitive or vascular changes. The small sample size limited the number of confounders included in the regressions. The CKD and non-CKD groups differed in racial makeup, education level, and comorbidity, which may have influenced the results. Antihypertensive medications were not held before vascular testing, which could have affected vascular compliance measures. The positive finding was an additional subgroup analysis in participants without CKD, not the main analysis. The study did not test whether reducing sedentary time or increasing breaks changes cognition or vascular function.
Declared interests
The remaining authors reported no actual or potential conflict of interest for this nursing continuing professional development activity. The supplied text does not state who funded the study.
The easy way to misread this
Do not conclude that reducing sedentary time will improve cognition or vascular function. No sedentary behavior intervention was tested, the main moderation analysis was null, and the positive result occurred only in an exploratory subgroup of participants without chronic kidney disease.