RNSurveyEuropean journal of cardiovascular nursing2026

The impact of fear of recurrence and progression on mental health after spontaneous coronary artery dissection: the role of illness uncertainty.

Sarah T Clarke, Barbara M Murphy, Michael R Le Grande and 7 others

PMID 41878776

WHAT IT FOUND

Among SCAD survivors, fear of recurrence was linked to depression and cardiac distress, and illness uncertainty was linked with stronger relationships for those outcomes.

It did not show a stronger relationship for anxiety in the main analysis.

Key findings

01In the main analysis, illness uncertainty was linked with a stronger relationship between fear of recurrence and depression and cardiac distress, but not anxiety.

02After a later check removed one questionable fear item, illness uncertainty was linked with a stronger anxiety relationship.

03The analysed sample was 270 SCAD survivors, and 20% met the anxiety cut-off, 21% the depression cut-off, and 15% the cardiac distress cut-off.

STILL TO COME

How it was doneWhat they foundWhat it means for RNs

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What it does not show

The study measured fear, uncertainty, and mental health at one time, so it cannot show that fear or uncertainty causes later depression or distress. 40 participants were excluded because the required measures were late in the survey, which may bias the results. The sample was mostly partnered, employed, university-educated, Australian-born women, and only 13% had SCAD in the past year, so it may not represent all survivors. The fear scale was not validated in cardiac patients, and one item may have measured general anxiety; removing it changed the anxiety result. The analysis did not include covariates such as age, sex, pre-existing mental health conditions, or time since SCAD. Illness uncertainty was measured with a general community scale, not a SCAD-specific measure.

Declared interests

The supplied text lists funders: Sarah Ford and SCAD Research Inc, Australian Government Research Training Program Scholarship, National Heart Foundation of Australia, NSW Health Cardiovascular Senior Scientist, US National Institutes of Health, Leducq Foundation, Snow Medical, Bourne Foundation, Angles Family Foundation, SCAD Research Inc, and Agilent. It does not state author conflicts.

The easy way to misread this

Do not conclude that reducing uncertainty will improve mental health or that fear causes depression. The study measured people at one time, and the anxiety result was not clear in the main analysis; it became clearer only after a later check changed the fear scale.

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