The effects of preceding exercise on myocardial damage in rats.
Seung Hee Hyun, Young Mi Kim, Su Jin Park
PMID 28356642WHAT IT FOUND
High-intensity treadmill training in rats before a long run kept heart damage blood markers lower than no preceding training.
Moderate training also lowered them. This is an animal finding, not evidence for people.
Key findings
01After prolonged exercise, cTnI was 0.01 ± 0.00 ng/ml in the control group, 0.08 ± 0.02 ng/ml in the high-intensity group, 0.59 ± 0.40 ng/ml in the moderate-intensity group, and 1.54 ± 0.74 ng/ml in the non-exercise group.
02The high- and moderate-intensity groups had higher cTnI than the control group and lower cTnI than the non-exercise group.
03NT-proBNP was 27.8 ± 8.7 pg/ml in the control group, 29.7 ± 10.5 pg/ml in the high-intensity group, 38.5 ± 12.8 pg/ml in the moderate-intensity group, and 58.5 ± 15.3 pg/ml in the non-exercise group.
STILL TO COME
How it was doneWhat they found
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What it does not show
The study was done in rats, not people, so it does not show what would happen in a patient. The control group did not perform the prolonged treadmill run, so it cannot be compared directly as an untrained group doing the same exercise. The paper says it investigated CK-MB, but the supplied text reports only cTnI and NT-proBNP. Only blood markers were measured. No human cardiac event, symptom, function or safety outcome was reported. Blinding, dropout handling and detailed randomisation are not described.
The easy way to misread this
Do not use this to tell patients that high-intensity training prevents myocardial damage. The study measured blood markers in rats, and the control group did not perform the prolonged run.