OtherMolecular autism2019

The distribution of autistic traits across the autism spectrum: evidence for discontinuous dimensional subpopulations underlying the autism continuum.

Ahmad Abu-Akel, Carrie Allison, Simon Baron-Cohen and 1 others

PMID 31149329

WHAT IT FOUND

Adult autism trait scores did not split into a clear line.

The score separating groups changed by sex and by sample makeup. Do not treat a questionnaire cutoff as a fixed diagnostic rule.

Key findings

01The two distributions intersected between 30 and 32 on the AQ scale in the enriched sample.

02The estimated AQ cutoff was 31.96 in the female-only sample and 30.16 in the male-only sample.

03In the prevalence-true resampled analysis, the estimated cutoff was 34.18, higher than the enriched-sample mean cutoff of 31.53.

STILL TO COME

How it was doneWhat they found

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What it does not show

The sample was collected online as a convenience sample, so it may not represent all autistic or neurotypical adults. Autism diagnoses were self-reported and not clinically verified. Some people in the neurotypical group may have been clinically autistic but undiagnosed. Only the AQ was used, so the result depends on a self-report measure. Females were overrepresented in both the autistic and neurotypical groups. The enriched sample had far more autistic people than the general population, so its cutoff may not apply to a general population. The prevalence-true sample was created by resampling the enriched data, not by recruiting a population sample. The model was limited to two components, so it may not capture all subgroups. The authors state that the findings should not be used to choose a fixed cutoff.

Declared interests

The article lists funding from the Innovative Medicines Initiative. No other conflict-of-interest statement is included in the supplied text.

The easy way to misread this

Do not use these AQ cutoff scores as diagnostic thresholds. The study did not evaluate diagnostic properties, diagnoses were self-reported, and the cutoff changed with sex and sample prevalence.

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The study

Participants
4717 adults (3016 female, 1701 male; 811 autistic, 3906 neurotypical)
Certainty of evidence
Low

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    Cite

    Ahmad Abu-Akel, Carrie Allison, Simon Baron-Cohen, et al. The distribution of autistic traits across the autism spectrum: evidence for discontinuous dimensional subpopulations underlying the autism continuum. Molecular autism. 2019.

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