The association of multidimensional sleep health with adiposity in heart failure with preserved ejection fraction.
Brittanny M Polanka, Lisa R Yanek, Allison G Hays and 5 others
PMID 36516532WHAT IT FOUND
In stable heart failure with preserved ejection fraction, better sleep health was associated with lower BMI and thigh intermuscular fat.
More night movement and more waking during sleep were linked to more thigh fat but less liver fat. These are associations, not proof of cause.
Key findings
01Every unit higher sleep health score was associated with a 2.5-unit lower BMI and 22% lower thigh intermuscular fat.
02Every unit higher night movement was associated with nearly 100% greater thigh intermuscular fat and 47% lower liver fat; every unit higher fragmentation was associated with 88% greater thigh intermuscular fat and 49% lower liver fat.
03High sleep-disordered breathing risk was associated with a higher abdominal visceral-to-subcutaneous fat ratio and lower thigh fat measures.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
The sample was small, especially for MRI outcomes (n = 22), so estimates may be unstable. The design was cross-sectional, so it cannot show whether poor sleep caused more fat, more fat caused poor sleep, or both were related to other factors. Analyses were only unadjusted or age-adjusted; the small sample prevented adjustment for sex or other potential confounders. Sleep-disordered breathing risk was measured by questionnaire, not polysomnography, and the low-risk group had only seven participants. High CPAP adherence (64%) may have biased some associations toward the null. The sample was mostly women (74%) and had a mean BMI of 41.4 kg/m^2, so it may not represent other HFpEF populations.
Declared interests
The supplied text does not include a conflict-of-interest declaration. Publication types indicate NIH extramural and non-U.S. government research support.
The easy way to misread this
Do not conclude that treating sleep will lower weight or fat in HFpEF. The study was cross-sectional, small, and only reports associations; it did not test a sleep intervention.