The Association Between Patient-Reported and Objective Oral Anticancer Medication Adherence Measures: A Systematic Review .
Thomas M Atkinson, Vivian M Rodríguez, Mallorie Gordon and 5 others
PMID 27541550WHAT IT FOUND
In adults taking oral anticancer medications, patient-reported adherence was higher than objective measures in studies that compared them directly.
Self-report may overestimate true adherence when used alone.
Key findings
01Eight included studies were reviewed; four found a significant positive association between patient-reported and objective oral anticancer medication adherence.
02In three studies that directly compared methods, patient-reported adherence was higher than objective adherence. A breast cancer study reported 88% self-reported adherence versus 78% objective adherence.
03The remaining study reported no significant correlation between patient-reported and objective oral anticancer medication adherence.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Only eight studies were included, and no meta-analysis was possible because most studies did not report effect sizes. Adherence measures were not standardized across studies, so comparison is difficult. Only a minority of studies directly compared patient-reported and objective measures. The review included only anticancer medications, so it does not address how other oral medications may affect adherence. The included studies had mixed cancer types and medications, so results may not apply to a specific cancer or drug. Race was reported in only two studies, and ethnicity was not reported in any study.
The easy way to misread this
Do not conclude that patient self-report is as accurate as objective adherence measures. In the three studies that directly compared methods, patient-reported adherence was higher than objective adherence. Self-report may overestimate true adherence.