Temporary Botulinum Immobilization of Residuum Muscles for Facilitation of the Initial Ingrowth of Skin to the Porous Skin and Bone Integrated Pylon in the Technology of Direct Skeletal Attachment: Large Animal Model.
Zachary Bohart, Charles Cassidy, David Merrill and 4 others
PMID 35891709WHAT IT FOUND
In three pigs, Botulinum toxin A failed to weaken leg muscles.
Botulinum toxin B caused muscle paralysis but killed one animal at a high dose. A lower dose produced temporary paralysis, peaking at four weeks, allowing the animal to recover.
Key findings
01Botulinum toxin A showed no effect on muscle strength or gait in the first pig.
02A high dose of Botulinum toxin B caused severe toxicity and euthanasia in the second pig.
03A lower dose of Botulinum toxin B in the third pig caused temporary paralysis that peaked at four weeks before recovery.
STILL TO COME
How it was doneWhat they found
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What it does not show
The study involved only three animals, which is too small to determine safety or effective dosing for humans. One animal died from the treatment, highlighting significant safety risks at the tested doses. The study tested the effect on muscle movement in pigs, not the actual success of skin integration for prosthetics in humans. Authors were employed by the companies developing the implant technology.
Declared interests
Several authors were employed by DaVinci Biomedical Research Products and Poly-Orth International, the companies involved in developing the implant technology.
The easy way to misread this
Do not interpret this as evidence that botulinum toxin is safe or effective for human prosthetic care. The study was in pigs, one animal died from the treatment, and the findings only suggest a timing window for muscle weakness in animals, not a clinical protocol for people.