Suicide, quality of life, and psychotropic medication use in women with breast cancer.
Leonardo Felipe Ferreira de Carvalho, Adriana Inocenti Miasso
PMID 42585453WHAT IT FOUND
In 102 women with breast cancer, 15.7% were classified as at risk of suicide.
Psychotropic medication use was associated with higher suicide risk and lower quality of life in all four WHOQOL-bref domains.
Key findings
01The MINI classified 15.7% of the 102 participants as at risk for suicide.
02Psychotropic medication use was associated with suicide risk, with an odds ratio of 7.92 (95% CI 2.5 to 25.3; p=0.0005).
03Psychotropic medication use was negatively associated with quality of life in the physical, psychological, social relationships, and environment domains.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study was cross-sectional, so it cannot show whether psychotropic medication use led to suicide risk or whether greater distress led to medication use. Participants were recruited from one mastology outpatient clinic in southeastern Brazil, so the results may not apply to other settings or populations. The sampling was non-probabilistic and the study was described as exploratory with 102 participants. Data were self-reported on sensitive topics, so psychological distress and suicide risk could be underreported or overreported. The association was reported for psychotropic medication use overall, so the contribution of benzodiazepines, antidepressants, or other medications cannot be separated. The study reports associations, not tested interventions.
The easy way to misread this
Do not read the odds ratio of 7.92 as proof that psychotropic medication causes suicide risk. The study was cross-sectional, and the analysis grouped all psychotropic medications together, so it cannot separate benzodiazepines, antidepressants, or other medications.