Successful Treatment of Chronic Lower Extremity Ulcers with Allogeneic Platelet-Rich Plasma and Artificial Dermis: A Case Report.
Qiannan Zhao, Yuanyuan Ma, Yuquan Lu and 2 others
PMID 31764145WHAT IT FOUND
A woman with hydroxyurea-related ulcers healed completely at 1 month after a bundled protocol: allogeneic PRP, artificial dermis, debridement, iodine/saline, polyurethane film, general dressings and a 1-week hydroxyurea break.
Key findings
01The patient had two painful chronic lower extremity ulcers that persisted for 3 months and enlarged despite oral antibiotics.
02After surgical debridement and 3 weeks of topical treatment, healthy granulation tissue did not form and wound contraction was not observed.
03Complete healing was reported at 1 month after the fourth treatment, with no recurrence at 6 months, but the patient also stopped hydroxyurea for 1 week.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
This is a case report, so it cannot show that the treatment works. The patient received allogeneic PRP, artificial dermis, debridement, iodine/saline, polyurethane film, general dressings, and stopped hydroxyurea for 1 week, so the contribution of any single component cannot be separated. The patient concealed stopping hydroxyurea for 1 week, which could have affected healing. There is no uniform standard for PRP preparation and quality. The paper says future studies with more wounds are needed.
The easy way to misread this
Do not read complete healing as evidence that allogeneic PRP works. This is a case report, and the patient received allogeneic PRP, artificial dermis, debridement, iodine/saline, polyurethane film, general dressings, and stopped hydroxyurea for 1 week without telling her doctors.