Staying Strong and Healthy During Androgen Deprivation Therapy.

The original plan was 150 participants, but recruitment barriers led to a revised target of 40, and the study was not powered to detect between-group differences. Thirty-nine participants were enrolled and 38 completed baseline assessments, with attrition of 22% at 6 months and 27% at 12 months. The attention control group received regular nurse calls and general prostate cancer information, so any benefit from the intervention's exercise, nutrition, and education components cannot be separated. Strength and graded exercise testing were done only for the intervention group, so there was no control comparison for those outcomes. The sample was mostly Caucasian, retired, college-educated men with metastatic disease, so results may not apply to other groups. Participants were recruited by convenience sampling from clinics, so they may not represent all men on ADT. Sleep disturbance was not objectively assessed, despite qualitative reports. No multivariate or time-trend analyses were possible because of the reduced sample size.

Do not conclude that the nurse-delivered exercise, nutrition, and ADT education program lowered LDL or cardiovascular risk. The primary LDL outcome did not show a significant between-group difference after correction, and the control group also received regular nurse calls.