Siyaphambili protocol: An evaluation of randomized, nurse-led adaptive HIV treatment interventions for cisgender female sex workers living with HIV in Durban, South Africa.

This is a protocol. It describes planned methods and early enrollment observations, not tested intervention effects. The planned analysis will not directly compare the interventions with standard care. Laboratory viral load processing causes one to two-week delays in randomization and re-randomization. Integrating research into routine service delivery creates coordination challenges. The study says fidelity and implementation outcomes will be monitored. Participants must be viremic at enrollment, so the trial does not test these interventions for women already virally suppressed. Pregnant women are excluded, so safety and effectiveness in pregnancy are not assessed. The planned population is cisgender female sex workers in Durban receiving community HIV services. The results may not apply to other populations or health systems.

The supplied publication types list NIH extramural and non-U.S. government research support. The text gives no author conflict-of-interest declaration.

Do not conclude that nurse-led mobile ART delivery or peer case management improves viral suppression. This is a protocol; the primary outcomes at 18 months have not been reported, and early enrollment data do not test the interventions.