Sex-specific differences in neuromuscular activation of the knee stabilizing muscles in adults - a systematic review.
Martina Steiner, Heiner Baur, Angela Blasimann
PMID 36788637WHAT IT FOUND
Evidence on sex-specific differences in knee muscle activation is contradictory.
Some studies show women activate quadriceps more during landing, others find no difference or opposite effects. Do not assume a distinct neuromuscular profile for women based on current data.
Key findings
01The review found no consistent sex-specific difference in neuromuscular activation, with studies reporting contradicting results or no significant differences.
02Three studies reported significantly higher activity in the vastus lateralis and medialis in females compared to males during jumping and cutting tasks.
03The included studies were all cross-sectional, and most had fair or poor methodological quality, limiting the certainty of the findings.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
All included studies were cross-sectional, so they cannot establish causality or track changes over time. Methodological quality was mixed, with only four studies rated as good quality; most were fair or poor. There was significant heterogeneity in the tasks performed (e.g., different jumps, cuts, walking vs running) and how EMG data was normalized, making direct comparison difficult. Sample sizes in individual studies were small, and many did not justify their sample size or account for confounders like strength or hormonal status. The review excluded adolescents, so findings do not apply to younger populations undergoing physical changes.
Declared interests
No specific funding sources or conflicts of interest were declared in the provided text.
The easy way to misread this
Do not interpret the three studies showing higher quadriceps activity in women as proof that women have a distinct 'quadriceps-dominant' risk profile. The majority of studies in this review found no difference or contradictory results, meaning this pattern is not a consistent finding across the literature.