SCN2A channelopathies in the autism spectrum of neuropsychiatric disorders: a role for pluripotent stem cells?
Karina A Kruth, Tierney M Grisolano, Christopher A Ahern, Aislinn J Williams
PMID 32264956WHAT IT FOUND
This review explains how SCN2A gene mutations cause autism and describes stem cell techniques researchers use to study these mutations in the lab.
It reports no patient treatments or outcomes, so it offers nothing to change clinical practice.
What this paper is
This is a narrative review of the genetic basis of SCN2A-related autism and the use of stem cell models to study it. It discusses mechanisms and experimental techniques but reports no new clinical trials or patient outcomes, so there are no findings to change clinical practice.
Declared interests
The work was supported by the Simons Foundation Autism Research Initiative, the National Institutes of Health, and the Roy J. Carver Charitable Trust.