Salivary Excretion Of Torque Teno Virus And Sars-Cov-2 In Children Who Underwent Kidney Transplantation.
Ísis Oliveira Arruda, Richarlisson Borges de Morais, Rodrigo Melim Zerbinati and 5 others
PMID 42788568WHAT IT FOUND
Salivary TTV copies did not track with SARS-CoV-2 PCR results in 31 pediatric kidney transplant recipients.
TTV was detected in 30 of 31, but the study did not show it was linked to infection status.
Key findings
01TTV viral replicas were found in saliva of 30 of 31 participants, and there was no significant association between TTV and SARS-CoV-2 (p=1).
02No relationship was observed between salivary SARS-CoV-2 PCR result and the number of TTV viral replications (p=0.426).
03A moderate negative correlation was found between serum tacrolimus and TTV log 10 CP/mL.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The sample was only 31 children and adolescents, and it was a convenience sample from a post-transplant clinic, so the estimates are imprecise. Participants were recruited at different times after transplant, with a maximum interval of 12 months, so post-transplant time may influence TTV levels. The study measured only associations at one time point and did not follow patients for rejection, infection, or death, so it cannot show that TTV predicts outcomes. The authors state that the pediatric transplant population is small and that comparison with other studies in the same population was not possible.
Declared interests
The study received support from FAPESP, CAPES, CAPES-PrInt, and Conselho Nacional de Desenvolvimento Científico e Tecnológico.
The easy way to misread this
Do not conclude that salivary TTV can predict SARS-CoV-2 infection or transplant outcomes. The authors mention a trend, but the statistical tests were null (p=1 and p=0.426), the sample was small and cross-sectional, and patients were not followed for rejection or infection.