Repetitive peripheral magnetic stimulation for pain, disability, and kinesiophobia in patients with chronic musculoskeletal pain: a systematic review and meta-analysis.
Jiaxin Pan, Yanbing Jia, Kuicheng Li and 6 others
PMID 40501206WHAT IT FOUND
Repetitive magnetic stimulation added to rehabilitation reduced pain and disability in adults with chronic musculoskeletal pain, but not fear of movement.
The eight trials were small, rated very low quality, and in several the stimulation was given alongside exercise.
Key findings
01Pooled across seven trials, repetitive peripheral magnetic stimulation reduced pain more than the control interventions (standardised mean difference -1.16, 95% CI -1.56 to -0.76), but the authors rated this evidence very low certainty.
02Fear of movement did not improve: two trials of 43 patients found no difference from control on the Tampa Scale for Kinesiophobia (mean difference -1.81, 95% CI -7.60 to 3.98, a result that includes no effect).
03In three trials the stimulation was combined with exercise, and in another with patient education, tendon gliding exercise and vitamins, so the effect of the stimulation on its own cannot be separated from the rest of the treatment.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
The authors rated the certainty of the evidence very low for all three outcomes, because of risk of bias, small samples and wide confidence intervals, so these results are not settled. Every included trial was judged to have 'some concerns' for risk of bias, and the review rests on only eight trials and roughly 180 participants. The trials differed widely in stimulation settings (frequency, intensity, coil type, number of sessions, total pulses) and in the populations treated, so no single protocol can be recommended and the authors say results should be adjusted to the individual clinical condition. In several trials the stimulation was given alongside exercise or usual treatment, so its own contribution cannot be separated from the rest of the care. No long-term follow-up data were available, so nothing is known about whether any benefit lasts. Only English-language trials published up to May 2023 were included. The participant numbers reported in different parts of the paper do not match: 186 participants included in the review, 177 recruited in the eight trials, and 91 in the experimental groups against 88 in the control groups.
Declared interests
The authors declare no conflict of interest with any financial organisation regarding the material in the manuscript. The work was funded by the Natural Science Foundation of Shandong Province (ZR2024MH143), a Co-construction of Traditional Chinese Medicine Technology Project of the National Administration of Traditional Chinese Medicine and provincial government (GZY-KJS-SD-2023-081) and the Scientific Research Innovation Plan Project of Shandong Second Medical University (2023BKQ001). The paper does not say whether the funders had any role in the study.
The easy way to misread this
Do not conclude from this review that repetitive peripheral magnetic stimulation works for chronic musculoskeletal pain. The authors themselves rated the certainty of the evidence very low for pain, disability and fear of movement, every included trial was judged to have 'some concerns' for risk of bias, and in several trials the stimulation was added to exercise or to usual treatment, so the improvement cannot be credited to the stimulation alone.
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