Relationship of Sleep Health and Endoscopic Disease Activity in Inflammatory Bowel Disease: Endoscopic Disease Activity and Sleep.
Kendra J Kamp, Linda Yoo, Kindra Clark-Snustad and 7 others
PMID 37540793WHAT IT FOUND
Most adults with IBD reported poor sleep, and poor sleep was associated with symptoms rather than endoscopic disease activity.
Ask IBD patients about sleep and consider sleep medicine referral when indicated.
Key findings
01Most adults with IBD had poor self-reported sleep: 59% exceeded the PSQI threshold for poor sleep.
02Participants with active endoscopic disease were significantly less likely to exceed the PSQI poor-sleep threshold than those with inactive disease (30% vs 72.2%, p=0.04).
03Participants with active clinical disease reported significantly greater sleep disturbance than those with inactive disease (57.3 vs 49.7, D=1.32).
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Small sample: only 28 participants, and only large effect sizes could be reliably detected with 80% statistical power. Actigraphy data were missing or excluded for some participants, leaving 26 actigraphy records. Data collection occurred during the COVID-19 pandemic, which may have affected routines and sleep. Endoscopic and clinical disease activity agreed poorly (Kappa 0.15), and only 30% of those with endoscopically active disease also had clinically active disease. The study did not examine disease location, medication effects, or environmental factors.
Declared interests
No funding source is stated. One author serves on advisory boards for Takeda, BMS, Pfizer, and AbbVie. Another author has received research support from AbbVie, Janssen, Takeda, Celgene, and Pfizer and serves on advisory boards for Cornerstones Health, Janssen, Eli Lilly, Bristol-Myers Squibb, and Pfizer. The remaining authors declared no conflicts.
The easy way to misread this
Do not conclude that endoscopic disease activity explains poor sleep. This preliminary study found fewer poor sleepers among participants with active endoscopic disease than among those with inactive disease (30% vs 72.2%, p=0.04), and it was too small to support a causal or treatment conclusion.