Relationship of HIV Status and Fatigue, Cardiorespiratory Fitness, Myokines, and Physical Activity.
Allison R Webel, Trevor Jenkins, Christopher T Longenecker and 7 others
PMID 31241504WHAT IT FOUND
Over six months, people living with HIV reported more fatigue than matched controls, while fitness was similarly low in both groups.
Fatigue was not linked to fitness in HIV, so exercise capacity alone may not explain it.
Key findings
01At baseline, PLHIV had significantly more fatigue than matched controls (mean ± SD 4.7 ±2.6 vs 2.8 ±2.5; p =0.01).
02VO2 peak and VO2 at anaerobic threshold were equivalent between PLHIV and controls at baseline (p =0.99 and p =0.95).
03Over six months, HIV status was associated with higher fatigue, decreased ventilatory efficiency, and reduced hand grip strength.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Small, single-site study. A p-value threshold of 0.10 was used, which can make chance findings look important. Participants were sedentary and at higher cardiovascular risk, so findings may not apply to more active or lower-risk people. BMI differed between groups, and adjustment cannot fully remove the effect of a small sample.
Declared interests
The authors declare no conflicts. The article metadata lists NIH extramural and non-U.S. government research support.
The easy way to misread this
Do not conclude that exercise training reduces fatigue in people living with HIV. This study only observed associations over six months and did not test an exercise intervention, and fatigue was not associated with cardiorespiratory fitness in the HIV group.