PTOTSLPCohortResearch in developmental disabilities2025

Relationship between anxiety and executive functioning among youth with Down syndrome.

Natalie A Snodgrass, Deborah J Fidler, Lina Patel and 4 others

PMID 40460701

WHAT IT FOUND

Executive function struggles and anxiety symptoms influence each other over time in youth with Down syndrome.

Shifting and working memory difficulties predicted higher anxiety a year later, while anxiety predicted later problems with shifting and initiating tasks.

Key findings

01Youth with co-occurring anxiety diagnoses showed greater challenges with shifting, emotional control, and working memory than those without anxiety.

02Baseline difficulties with shifting and working memory predicted increased anxiety symptoms one year later.

03Baseline anxiety symptoms predicted increased difficulties with shifting and initiating tasks one year later.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs

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What it does not show

The sample was predominantly White, non-Hispanic, and English-speaking, limiting generalizability to other cultural and linguistic groups. Anxiety diagnoses were based on parent report rather than clinical interviews or medical records, which may affect accuracy. Self-report of anxiety symptoms from the youth themselves was not included. The study used only two time points, which limits the ability to fully account for between-person variance in longitudinal models.

Declared interests

The authors declared no conflicts of interest. The research was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

The easy way to misread this

Do not assume that executive functioning deficits are the sole cause of anxiety or vice versa. The study shows a bidirectional relationship where each influences the other over time, and concurrent correlations were small to moderate, indicating these are largely independent constructs.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →