Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors.
Suzy Varderidou-Minasian, Lisa Hinz, Dominique Hagemans and 3 others
PMID 32460858WHAT IT FOUND
This lab study found protein changes in Rett syndrome stem cells as early as day 3 of neuronal development.
These changes were in cell structure and metabolism. It identifies biological targets for future research, not clinical treatments.
Key findings
01Proteins involved in immunity and metabolic processes were consistently changed between Rett and control cells at all time points studied.
02The difference in the number of altered proteins between Rett and control cells begins at early stages and increases at later progenitor stages.
03A large group of the altered proteins are involved in cellular processes implicated in classical features of typical Rett phenotypes, such as dendrite formation and axonal growth.
STILL TO COME
How it was doneWhat they found
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What it does not show
The study used cells from only one donor, so the findings may not represent all people with Rett syndrome. The study was performed on cells in a laboratory, not on patients, so it does not show clinical outcomes or treatment effects. The number of biological replicates was limited, requiring the grouping of samples across time points to detect consistent changes.
Declared interests
The authors declared no competing interests. The work was supported by NWO VICI and ZonMw VIDI grants.
The easy way to misread this
This is a laboratory analysis of cells in a dish, not a clinical trial. Do not interpret these protein changes as evidence of a treatment effect or a diagnostic marker for use in patients.