PTPilotArchives of rehabilitation research and clinical translation2025

Pilot Study to Assess the Ability of a 4-Week, Home-Based, Electrical Muscle Stimulation Program to Improve Lower Extremity Function and Reduce Sarcopenia in Older Individuals With Cancer.

Hisashi Kosaka, Tome Ikezoe, Kimitaka Hase and 13 others

PMID 40980522

WHAT IT FOUND

In 50 older patients with cancer, 4 weeks of home electrical muscle stimulation was associated with improved balance and walking speed in those with impaired lower extremity function, but not muscle strength or mass.

Key findings

01Median SPPB improved from 8.0 to 11.0 points after 4 weeks of home electrical muscle stimulation.

02This improvement was significant in the baseline SPPB ≤9 group (8.0 to 9.0 points) but not in the baseline SPPB >9 group (11.0 to 12.0 points).

03In the baseline SPPB ≤9 group, severe sarcopenia decreased from 66.7% to 36.4% after 4 weeks, but muscle strength and mass did not improve significantly.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

There was no control group, randomization, or blinding. Changes over time cannot be attributed to EMS. The sample was small and from one hospital: 50 patients were analyzed, and 86.0% had biliary tract cancer. Results may not apply to other cancers or settings. Patients were recruited during outpatient cancer visits, and 88.0% received drug therapy. The contribution of EMS cannot be separated from ongoing treatment, natural recovery, or repeated testing. Many statistical tests were used in a small sample. This increases the risk that some significant findings are chance. The program lasted only 4 weeks. Durability and safety over longer use are unknown. Muscle strength and mass did not improve significantly. The study does not support EMS as a treatment that increases muscle mass or strength.

Declared interests

The authors report no financial or nonfinancial disclosures. The EMS device is named as SIXPAD Foot Fit from MTG Co, Ltd.

The easy way to misread this

Do not conclude that portable EMS reverses sarcopenia. Muscle strength and mass did not improve significantly, and this single-arm study had no control group while patients were receiving cancer treatment or follow-up. The observed function and severe sarcopenia changes cannot be attributed to EMS.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →