Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice.
Kevin A Zwetsloot, R Andrew Shanely, Joshua S Godwin and 1 others
PMID 36188800WHAT IT FOUND
Oral 20-hydroxyecdysone restored muscle force by 7 days after eccentric injury in adult and old mice, while placebo did not.
This is mouse data, not tested evidence for people.
Key findings
01Oral 20E restored isometric torque to pre-damage levels by 7 days after eccentric injury in adult and old mice, while placebo did not.
02Adult and old mice had similar responses to eccentric muscle damage and recovery with 20E treatment.
0320E or placebo was given only after the eccentric damage protocol, so it could not have protected the muscle before injury.
STILL TO COME
How it was doneWhat they found
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What it does not show
This was a mouse experiment, not a human treatment trial. The adult placebo group had only n = 4 mice. Recovery was measured at a single time point, 7 days, so the study cannot say how long placebo mice would have needed to recover. Muscle damage scores were qualitative or semi-quantitative and were not statistically analysed. The study did not assess immune cells or inflammatory mechanisms. The study could not determine whether 20E affected connective tissue remodeling. The injury was produced by forced eccentric contractions in anesthetized mice, not by a clinical exercise programme.
The easy way to misread this
Do not conclude that 20-hydroxyecdysone speeds muscle recovery in patients. This was a mouse experiment with forced eccentric contractions and only a 7-day outcome. Human benefit was not tested.