Pathological similarities between degenerative enthesopathy and rheumatic enthesitis: the role of ECM stiffness and Wolff's Law-based mechanical stimulation as a therapeutic strategy.
Kang Ahn, Aerisa Ahn, Seung Jun Oh, Hyun Sung Kim
A theoretical framework paper, not a study.
It proposes that ECM stiffness links degenerative and inflammatory enthesopathy and that low-frequency vibration or dry needling might help, but the authors state no clinical trials have validated this yet.
What this paper is
This is a narrative review proposing a mechanistic framework (ECM stiffness as a shared substrate in degenerative and inflammatory enthesopathy) and a therapeutic hypothesis (Wolff's Law-based mechanical stimulation). It contains no original data, no patient cohort, no intervention results, and no primary outcome. The authors explicitly state that clinical validation of the proposed therapies is limited and that large-scale clinical trials are needed before standardized protocols can be defined.
Declared interests
The authors declared that no financial support was received for the work or its publication.
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