Nurse-Led Patient-Reported Outcome Assessment of Symptom Burden and Quality of Life in Myeloproliferative Neoplasms: An Observational Study.
Daniela Berardinelli, Carmen Fava, Valentina Bonuomo and 8 others
PMID 42669201WHAT IT FOUND
In 102 patients with myeloproliferative neoplasms, a nurse-led symptom diary review found moderate-to-severe symptoms were linked to lower quality of life, anxiety and depression.
Key findings
01In 102 treated patients with myeloproliferative neoplasms, 85% were symptomatic, and fatigue was the most frequent symptom at 72%.
02When researchers looked at each factor separately, moderate-to-severe fatigue, bone pain and itching were significantly associated with impaired global health (EORTC QLQ-F17 <75).
03When researchers looked at each factor separately, moderate-to-severe fatigue, inactivity and early satiety were significantly associated with clinical depression.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study was done at one Italian haematology clinic, so it may not apply to other health systems or patient groups. Only patients receiving drug treatment were included, so it says little about untreated MPN patients or those with very mild disease. The sample was 102 patients, and the MF and PV subgroups were only 20 patients each, so subgroup differences may be unstable. No formal sample size calculation was done, and multivariable models were not used because the sample was too small to adjust for several possible confounders. Data were collected at one time point, so the study cannot show how symptoms, quality of life, anxiety or depression changed over time. The nurse-led visit was not compared with usual care, so the study cannot show that the visit caused any improvement. Patients had to speak Italian and have no significant cognitive impairment, so the results may not apply to patients who cannot complete the forms.
Declared interests
The authors report no funding and no conflicts of interest.
The easy way to misread this
Do not conclude that the nurse-led symptom diary improves patient outcomes. This observational study had no comparison group and measured symptoms, quality of life, anxiety and depression at one time point, so it cannot show the visit caused benefit.