Nomogram for Deep Vein Thrombosis Prediction Post-Endovascular Thrombectomy in Acute Ischemic Stroke: A Retrospective Multicenter Observational Study.
Li Han, Teng-Wei Pan, Li-Li Yang and 6 others
PMID 40251701WHAT IT FOUND
After stroke clot removal, three markers identified higher DVT risk: lower limb NIHSS score ≥2, D-dimer ≥1.62 mg/L, procedure time ≥66 min.
The model predicted DVT moderately well but was not tested as care.
Key findings
01DVT was identified in 151 (23.6%) of 640 patients; 143 had distal DVT, and muscular calf veins were affected in 122 patients.
02Elevated D-dimer (≥1.62 mg/L), lower limb NIHSS score ≥2, and puncture-to-recanalization time ≥66 min were independently associated with higher DVT risk (ORs 3.237, 6.247 and 2.353).
03The nomogram showed AUCs of 0.822 in the training cohort, 0.751 in internal validation and 0.741 in external validation.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The data were retrospective, so the model was not tested prospectively. Most patients had only one ultrasound during hospitalisation and no later follow-up, so DVT after discharge may have been missed. DVT could not be confirmed before endovascular thrombectomy because of the urgency of treatment. Model development and internal validation came from one centre, and external validation came from only one other centre. The study did not test whether using the nomogram changed DVT prevention or patient outcomes.
Declared interests
The authors declared no conflicts of interest. Funding came from Zhejiang Provincial Basic and Public Welfare Research Program, Science and Technology Plan Project of Taizhou, Zhejiang Provincial Medicine and Health Research Foundation, and Saarland University.
The easy way to misread this
Do not conclude that using the nomogram prevents DVT or improves recovery. The study was retrospective and only tested prediction; it did not assign patients to care based on the nomogram.