PTOTCohortPM & R : the journal of injury, function, and rehabilitation2026

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study.

Robert J Trager, Collin M Labak, Anthony N Baumann and 2 others

PMID 41451528

WHAT IT FOUND

Spinal manipulative therapy by chiropractors did not increase the risk of spinal cerebrospinal fluid leaks compared to physical therapy exercise.

The study included 178,084 adults. Both groups had an identical leak rate of 0.03%. This suggests the leaks were likely caused by underlying symptoms prompting the visit, not the treatment.

Key findings

01After matching, there was no significant association between spinal manipulative therapy and spinal cerebrospinal fluid leak incidence compared to physical therapy exercise.

02The incidence of spinal cerebrospinal fluid leak was 0.03% in both the manipulative therapy and physical therapy cohorts.

03The absolute risk difference confidence interval excluded the predefined equivalence margin, allowing the study to rule out clinically meaningful differences in risk.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTs

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What it does not show

The study only included patients with spinal disorders and excluded those with serious spinal pathology, so the results do not apply to those groups. The follow-up period was short, limited to two months, which may miss delayed presentations. The data did not allow verification of the specific type or location of the cerebrospinal fluid leak via imaging. The study could not determine if specific manipulative techniques or doses were associated with risk. Selection bias remains possible, as patients seeking physical therapy may have different baseline health profiles than those seeking chiropractic care, despite matching.

Declared interests

The study was supported by the Clinical and Translational Science Collaborative of Northern Ohio, funded by the National Institutes of Health. Robert J. Trager received royalties from two texts on sciatica. The funders did not play a role in the study protocol or decision-making.

The easy way to misread this

Do not assume this study proves spinal manipulative therapy is risk-free for all patients. It specifically excludes those with serious spinal pathology like infection, malignancy, or fracture, where manipulative therapy is contraindicated. Additionally, the similar leak rates in both groups suggest that the leaks were likely present before the treatment started, causing the symptoms that led the patient to seek care.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →