Motor imagery-based neurofeedback in older adults: neural signatures and feasibility in a randomized controlled trial targeting age-related cognitive decline.
Diego Marcos-Martínez, Eduardo Santamaría-Vázquez, Sergio Pérez-Velasco and 6 others
PMID 41742172WHAT IT FOUND
Motor imagery neurofeedback did not beat sham feedback or classical cognitive stimulation for cognition in healthy older adults.
All groups, including those also doing weekly exercise, improved on some tests. The neurofeedback effect cannot be separated from exercise or task engagement.
Key findings
01The neurofeedback training group did not differ from the sham-feedback group or the classical cognitive stimulation group before training, after training, or in change scores.
02Significant within-group improvements on cognitive tests were found in all three groups, not only in the neurofeedback group.
03In the neurofeedback training group, 48.3% of participants were classified as unable to successfully self-regulate their brain activity during motor imagery trials.
STILL TO COME
How it was doneWhat they found
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What it does not show
The study was done in healthy older adults without neurological or psychiatric disorders, so it does not address people with diagnosed dementia, stroke, or other neurological conditions. All groups received weekly physical activity as well as cognitive training, so the contribution of neurofeedback alone cannot be separated from exercise or general task engagement. The control group could not be blinded, which may have influenced engagement or expectations. Some participants dropped out and were excluded, so the analysed sample was smaller than the recruited sample. The neurofeedback protocol was not personalised to each participant's brain signals, and training was one session per week, which may have been too low in dose to produce specific effects. Most participants were female, so sex-related effects are not well balanced. The authors did not collect participants' beliefs about which group they were in, so expectancy effects could not be checked.
Declared interests
Funders named in the supplied text are the European Union, Consejería de Educación, Junta de Castilla y León, and Universidad de Valladolid.
The easy way to misread this
Do not read the within-group cognitive gains as evidence that motor imagery neurofeedback works. The training group did not differ from sham feedback or classical cognitive stimulation, and every group also received weekly guided physical activity, so the contribution of neurofeedback alone cannot be separated.
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