Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.

WHAT IT FOUND

This review explains how laboratory-grown stem cells can model autism biology.

It contains no clinical trials or patient outcomes, so there is nothing here to change your current therapy practice.

What this paper is

This is a narrative review discussing how induced pluripotent stem cell (iPSC) models can be used to study autism spectrum disorder (ASD) in a laboratory setting. It describes experimental techniques for growing and analyzing neurons in culture, rather than reporting clinical outcomes, patient populations, or therapeutic interventions. Because it contains no direct evidence regarding patient care or treatment efficacy, there are no findings here that would change clinical practice.

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