Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model.
Emmanuel Matas, Alexandre Maisterrena, Mathieu Thabault, Eric Balado, Maureen Francheteau, Anais Balbous, Laurie Galvan, Mohamed Jaber
PMID 33468258WHAT IT FOUND
This paper describes motor and social deficits in mice with a genetic mutation linked to autism.
It does not involve human participants or clinical treatments, so it offers no direct guidance for therapy.
What this paper is
This is a preclinical study investigating behavioral and cellular changes in a genetically modified mouse model of autism. It reports on animal physiology and behavior, not on human patients or clinical interventions, so there is nothing here to change your practice with patients.
The easy way to misread this
Do not apply these findings to human patients. The study measures gait and social behavior in mice, which may not translate to human motor control or social communication.