PilotJMIR rehabilitation and assistive technologies2025

Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation.

Fredrick Zmudzki, Rob J E M Smeets, Jan S Groenewegen and 1 others

PMID 40344193

WHAT IT FOUND

Machine learning profiles matched clinician judgments in 14 of 17 chronic pain patients.

The tool helped discuss treatment options and was rated useful for shared decision-making, though it did not change the clinical recommendation in any case.

Key findings

01The machine learning prognostic profiles were consistent with clinician assessments in 82.4% (14/17) of cases.

02Clinicians reported the profiles were helpful for shared decision-making and individualized planning when discussed with patients.

03The profiles were considered helpful in 88.2% (15/17) of initial assessments when including cases where they supported a decision not to proceed.

STILL TO COME

How it was doneWhat they found

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What it does not show

The sample size was very small (17 patients), limiting the reliability of the findings. The study was conducted at a single clinic, so results may not apply to other settings. The machine learning models were run manually for each patient, which is not feasible for routine clinical use. The study did not measure whether the tool actually improved patient outcomes, only whether it matched clinician judgments.

Declared interests

None declared.

The easy way to misread this

Do not assume this tool is ready for clinical use. The profiles were generated manually over three weeks for 17 patients, and the study only showed they matched existing clinician judgments, not that they improved patient care or treatment outcomes.

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The study

Participants
17
Certainty of evidence
Very low

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    Cite

    Fredrick Zmudzki, Rob J E M Smeets, Jan S Groenewegen, et al. Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation. JMIR rehabilitation and assistive technologies. 2025.

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