Influence of early hemodialysis on the septic acute kidney injury outcome.
Cléria Alves de Queiroz, Marcelo Rodrigues Bacci
PMID 36346185WHAT IT FOUND
In 40 ICU patients with sepsis and acute kidney injury, early hemodialysis did not change death or kidney recovery compared with late hemodialysis.
The study did not show that dialysis timing affects septic acute kidney injury outcomes.
Key findings
01The study outcomes were death, end-stage kidney disease, or reversal of kidney dysfunction, and there was no significant difference between the early and late hemodialysis groups.
02When patients were grouped by death and survival, vasopressor use was associated with death.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
The study used a convenience sample of 40 patients, so the groups were small and differences could be due to chance. Hemodialysis timing was chosen by nephrologists or intensivists, not randomly assigned, so patients receiving early and late treatment may have differed in ways not measured. The paper reports mechanical ventilation and vasopressor use, but it does not list or control every co-treatment, so the contribution of hemodialysis timing alone cannot be separated. The authors state that the study was observational and could not control the groups formed. The authors state that high mortality made it difficult to obtain a larger sample.
The easy way to misread this
Do not read this as showing that earlier hemodialysis improves survival or kidney recovery. The early and late hemodialysis groups did not differ in outcomes, and the study was a small observational comparison in which patients also received mechanical ventilation and vasopressors, so the timing of dialysis cannot be separated from those other treatments.