Incidence and Risk Factors of Delayed Chemotherapy-Induced Nausea and Vomiting Among Adult Patients: A Cross-Sectional Study.
Mimi Zheng, Qi Zhang, Liping Ni and 7 others
PMID 41934104WHAT IT FOUND
Among 326 chemotherapy patients, 34.7% reported delayed nausea or vomiting; anxiety, motion sickness and high-emetogenicity chemotherapy were significant risk factors.
Key findings
01Of 326 participants, 113 (34.7%) reported delayed nausea and/or vomiting.
02Anxiety, motion sickness and high emetogenicity were significant risk factors for delayed nausea.
03Anxiety was the single significant risk factor for delayed vomiting in the main model.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
This was a cross-sectional study, so it cannot show that any risk factor caused delayed CINV. All participants came from one large tertiary hospital in Shanghai, so findings may not transfer to other settings. Symptoms were assessed only on the third day after chemotherapy, which may miss delayed CINV occurring later. Anxiety and sleep disorders were measured by basic self-report rather than validated scales. The anxiety odds ratio had a very wide confidence interval, making the estimate unstable. The post hoc model for delayed vomiting had only 43 events, so its estimates require caution. BMI was not selected in the LASSO analysis.
Declared interests
The study was funded by the Key Weak Discipline Development Fund at Zhongshan Hospital, Fudan University. The authors declared no conflicts of interest.
The easy way to misread this
Do not conclude that anxiety causes delayed CINV or that treating anxiety will prevent it. This was a cross-sectional study of associations, the anxiety odds ratio had a very wide confidence interval, and no intervention was tested.