Identifying Adolescent and Young Adults' Preferences for Oncology Symptom Management Clinical Trial Participation.
Robert Knoerl, Liat Smener, Katherine Grandinetti and 8 others
PMID 39888653WHAT IT FOUND
AYA cancer survivors preferred symptom-management trials with a treatment type they valued and a topic they saw as important.
They favored shorter, once-weekly, under-30-minute visits and electronic surveys; 64% chose an alternative trial design.
Key findings
01Type of new treatment (22.9%) and perceived importance of the study topic (19.5%) were the trial features AYAs considered most important.
02Preferred trial levels included electronic surveys, under-30-minute visits, $25 per week reimbursement, once-weekly treatment, four-week treatment, and no follow-up.
03In the simulator, 64% of participants preferred an alternative symptom-management trial scenario over a typical scenario.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The sample was small and mainly female, white, and breast cancer, so results may not apply to other AYA cancer survivors. Preferences were based on hypothetical trial scenarios, not real trials or actual treatment outcomes. Some trial features that might affect real enrollment, such as randomization to a control group, were not tested. External factors such as cancer center resources or provider promotion of trials were not included. Symptom inventory data were missing for conjoint survey participants because of a data collection and storage error.
The easy way to misread this
Do not read the 64% preference for an alternative trial as evidence that such trials work or that AYAs will enroll in real trials. The study used hypothetical scenarios in 52 participants, and the authors said generalizability is low.