Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction.
Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz, Oliver Brüstle
PMID 33308283WHAT IT FOUND
Stem cell models are used to study autism-related neuronal changes.
This review reports no original patient outcomes or therapy results, so there is nothing here to change clinical practice.
What this paper is
This is a narrative review of human stem cell and animal models for autism spectrum disorder-related neuronal dysfunction. It summarizes laboratory findings about genes, neurons and network activity. It reports no original clinical trial, cohort or patient outcome, so there is no finding here to change therapy practice.
The easy way to misread this
Do not read the stem cell or animal model findings as evidence that a treatment works for patients with autism. This paper reviews laboratory models and does not report clinical outcomes.